Scientists discovered a new gene type and called it the Borg DNA. Credit: Pixabay

Researchers Find “Borg DNA” Capable of Assimilating Genes–10 Things You Need to Know

Named after the Borg civilization from Star Trek.

In the process of genetic analysis of the microbial community of a swamp, American scientists discovered a new type of huge genetic element, probably capable of assimilating the genes of archaea. For this reason, they were named after the Borg civilization from the science fiction series Star Trek – Borg DNA. Apparently, these previously unknown elements belong to microorganisms that oxidize methane.

In addition to bacteria and eukaryotes, which include mammals, taxonomists distinguish the third domain of living organisms – archaea. Phenotypically, they can be called microbes, but they are quite different from bacteria biochemically, which is why they were separated into a separate group.

Many representatives of archaea live in extreme conditions – at high temperatures, in conditions of increased salinity, high pressure.

In addition, some species of archaea attract the attention of ecologists, as they actively participate in the circulation of atmospheric methane, a greenhouse gas.

Different types of archaea can both produce methane, releasing it into the atmosphere, and metabolize it. These species live in anoxic conditions, which are typical for swamps, for example.

Everything you need to know about the new Borg DNA

1. Geneticists from the University of California at Berkeley studied one of these communities of swamp archaea by analyzing their metagenome, that is, a “hodge-podge” of DNA from all microorganisms from a given sample.

2. This method is often used for DNA analysis of archaea since it is difficult or impossible to culture them in the laboratory. During the analysis, scientists discovered previously unknown elements, for four of which they managed to completely restore the DNA sequence.

3. These turned out to be large (from 600 to 900 thousand base pairs) linear DNA molecules, limited by long inverted repeats. Geneticists suggested that molecules exist in cells as separate extrachromosomal elements.

4. The elements turned out to be enriched with repetitive sequences, had the start of the beginning of replication (copying), as well as a system of protection against mobile elements in the CRISPR-Cas format.

5. In addition, they contained many new genes with unknown functions. However, researchers identified 20 percent of all genes as belonging to the archaea genus Methanoperedens. Analysis of different soil samples showed that the presence of genetic elements coincides with the presence of these archaea, so the Methanoperedens were preliminarily called the hosts of the unknown DNA.

Borg DNA sequencing diagrams. Credit: Basem Al-Shayeb et al / BioRxiv, 2021
Borg DNA sequencing diagrams. Credit: Basem Al-Shayeb et al / BioRxiv, 2021

6. Scientists dismissed the hypothesis that they are part of the genome of an unknown species since they did not find genes encoding the protein synthesis apparatus on the elements. The Methanoperedens genes appear to have entered these molecules by horizontal transfer.

7. For their ability to integrate genes, researchers named the new elements Borg – after the race, or civilization, of creatures from the StarTrek series that assimilated various technologies and objects. The four fully assembled Borgs were named separate colors – black, cyan, magenta, and lilac.

8. Scientists noted that the Borgs are completely different from known extrachromosomal elements such as plasmids, as they do not contain any elements characteristic of them. However, it is possible that these elements can be transferred between cells as some other extrachromosomal elements.

9. Among the archaeal genes found on the Borgs, geneticists especially noted the gene for the key enzyme of methane oxidation.

10. If we assume that Borg genes are transmitted between cells in the process of horizontal transfer, then the genes for methane metabolism can thus spread between microorganisms, participating in the evolution of archaea.

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Ainsworth, C. (2021, July 15). Weird ‘Borg’ DNA found in microbes takes in genes from other organisms. New Scientist.
Al-Shayeb, B. (2021, January 1). Borgs are giant extrachromosomal elements with the potential to augment methane oxidation. bioRxiv.
Dance, A. (2021, July 16). Massive DNA ‘Borg’ structures perplex scientists. Nature News.
Ferreira, B. (2021, July 15). Newly-discovered ‘Borg’ DNA Is unlike anything scientists have ever seen. Newly-discovered ‘Borg’ DNA Is unlike anything scientists have ever seen | College of Chemistry.
Pennisi, E., Cohen, J., Wadman, M., Clery, D., Stone, R., Casassus, B., Ibrahim, M., Fritts, R., Oza, A., & Viveros, A. (2021, July 16). Mysterious DNA sequences, known as ‘Borgs,’ recovered from California mud. Science.
Starr, M. (n.d.). Mysterious New ‘Borg’ DNA Seems to Assimilate Genes From Different Organisms. ScienceAlert.

Written by Vladislav Tchakarov

Hello, my name is Vladislav and I am glad to have you here on Curiosmos. My experience as a freelance writer began in 2018 but I have been part of the Curiosmos family since mid-2020. As a history student, I have a strong passion for history and science, and the opportunity to research and write in this field on a daily basis is a dream come true.

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